Pharmacological evaluation of Apium leptophyllum (Pers.) on bronchial asthma

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Pharmacological evaluation of Apium leptophyllum (Pers.) on bronchial asthma

OBJECTIVE The present study was to investigate the antiasthmatic potential from the flavonoid fraction of Apium leptophyllum fruit (FFALF) to validate its traditional claim. MATERIALS AND METHODS The antiasthmatic activity of FFALF was evaluated by histamine or acetylcholine-induced bronchospasm model in guinea pigs, compound 48/80 induced mast cell degranulation in albino rats and histamine-...

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Bronchial asthma is a heterogeneous, complex, chronic inflammatory and obstructive pulmonary disease driven by various pathways to present with different phenotypes. A small proportion of asthmatics (5-10%) suffer from severe asthma with symptoms that cannot be controlled by guideline therapy with high doses of inhaled steroids plus a second controller, such as long-acting β2 agonists (LABA) or...

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Pulmonary Artery Agenesis with Bronchial Asthma

Unilateral Pulmonary Artery Agenesis (UPAA) is a rare congenital anomaly during the 4 th  week of gestational age. It is defined as an absence of pulmonary parenchyma and its supporting artery. A 9-year-old girl was admitted to our hospital because of chronic cough. Chest examination showed a decrement in lung sound of right hemi-thorax with expiratory wheeze. Chest radiography (CXR) revealed a...

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Effects on Bronchial Asthma

Ten patients with bronchial asthma and ten control subjects were exposed to sidestream cigarette smoke (passive smoking) for one hour in an environmental chamber. All subjects showed the same increase in carboxyhemoglohin as a result of the exposure: 0.40 percent. The asthmatic group demonstrated a significant linear decrease in pulmonary function during this exposure. After one hour of smoke, ...

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ژورنال

عنوان ژورنال: Journal of Pharmacy And Bioallied Sciences

سال: 2016

ISSN: 0975-7406

DOI: 10.4103/0975-7406.199343